At that time, the S-mount 50mm lenses should be much more advantageous, because there were no restriction to clear the mirror. I would bet that S-mount standards would perform much better than the F-mount siblings on film.
On digital bodies, there should be another story. The angle of the light rays from a rangefinder lens hitting on the sensor is much more steep than those from the F-mount lens. So, the peripherals would suffer more.