The Copal shutter would be a part of the front plate so the strain might be severe with that apparently heavy zoom lens. And considering the rather small size of prime lenses in this focal range, and the ease of snapping in or out a front plate with the respective lens mounted, I'm a little surprised the company went to the efforts of making that huge zoom lens.
I did a lot of work in the film days with 150/5.6, 210/5.6, and 270/6.3 T-ED Nikkors on my 4x5" Arca-Swiss camera. If I deployed the 360/8 or 500/11 Nikkor-T ED, an extension bellows was required.