Even though I only shoot RAW, I set sharpness at +9 for easier focussing in LV. Reason enough.
In Lightroom, I set the sharpening between +25 (default) and +40, depending on the lens (some just do not need it; Zeiss 135/2 is one example), the ISO (oversharpening an ISO12800 pic may not look good), and the style of the shot (portraits are not about counting those white hairs).