It would be interesting to hear about your workflow, Toby. Which app do you use first, and why?
What I have found works for me is the following: First I open in Adobe Camera Raw and adjust exposure and contrast. I sometimes add what Adobe calls "Texture"--a kind of sharpening, and sometimes a small bit of Clarity and/or Dehaze if it is an old lens, uncoated or otherwise poor in contrast. I go the the Lens Correctoins tab and do color defringing, which is often necessary with older lenses, and correct for vignetting.
Then in Photoshop I generally start with Piccure Plus. From there I might or might not sharpen further using Topaz Sharpen AI. Some of the older lenses benefit from both. I go as far as I can unless I get artifacts. Sharpen AI has a very good denoise function, but if I need something more aggressive, at this point I use Topaz DeNoise AI. This is by far the best noise reduction tool that I have come across. It really can reduce noise tremendously without destroying detail or adding a lot of artifacts. Occasionally I have found it better to use DeNoise out of the gate as a first step--if the original image is very noisy--as the Sharpening tools can increase the contrast of the noise itself enough to make it difficult to tackle later, but I have found, when possible, that reducing noise later in the process preserves details better. However this really seems to depend on the image--I haven't found a set formula, but that being said, I try to work always at base ISO and generally am not bothered by noise.
AT this point I run the image through Topaz Detail, which tends to emphasize low contrast details--not the smallest details as the above sharpening tools, but larger details, which tends to emphasize the pattern of bokeh. There are three levels of detail. I usually only boost small and medium details, and those only a bit. Boosting the larger details give an unnatural look for me. This has the effect of boosting bokeh structures, without overly sharpening finer details.
As a final step I sometimes use Topaz Clarity, which is a versatile tool for adjusting various levels of contrast. This too can boost bokeh structures, or add more punch to images shot with low contrast lenses, or both.
Hope that is somewhat clear.