My understanding is that digital sensors have one base, or natural ISO and all others are achieved by amplification and attenuation of the base signal, hence 'noisy' high ISO; a bit like a faint HAM radio signal from half way around the world needs a lot of amplification, so does a faint image. In neither case are you likely to get a clear result. I believe for most sensors the base, or natural ISO has been 200 ISO but perhaps recently that may have dropped to 100 ISO?
Amplification and attenuation has come a long way since the D1.
Using an ISO below the natural ISO for the sensor, if seeking a better image, rather than simply a longer exposure, may be a wild goose chase.
As for the intermediate settings, I firmly believe when somebody is *looking* for a problem, they will find one, then perhaps attribute it to the wrong cause.