CS6 and El Capitan works (unless there is a specific bug, I haven't found any problem in common usage). LR 6.1 works perfectly ! There could be some various problems with any new OS X upgrade, but here I do think the culprit is Adobe playing on two paths, trying to push people on CC (new features, etc.) while the standalone "classical" softwares stay a bit behind if not definitely lost (CS6 being the lats version, the future being CC) !