Braze yourself and go into battle mode. You probably will find the outcome very valuable at the end, perhaps not so during the battle itself
Store location details with the files so make the sorting and key wording easier later.
Dedicate a small laptop or obsoleted PC to the scanner, and give it access to a high-capacity disk. Don't forget to run backups on a regular basis.
At the peak of my scanning activity, I had two film scanners 5000/4000ED with slide feeders hooked up to separate Thinkpads, a third Thinkpad for an Epson V750 flatbed scanner (prints and negatives), a stationary PC with SCSI for my trustworthy Agfa flatbed scanner (for prints), and finally, a second stationary box for the Ls8000ED. All machines were networked over Ethernet Gigabit LAN and connected to two NAS units that served as redundant mirrors. I played the stereo at high volume most of the time, read a good number of books, and drank a lot of coffee. Once in a while I did the rounds and reloaded the scanners with fresh material. Nothing I want to do on a permanent basis of course, but doable and efficient.